Nicole is a pioneer of novel genomics and bioinformatics techniques. In 2008 she described a new technology that revolutionized the way we study RNA. Now called RNA-seq, this technique was widely and rapidly adopted, and was the foundation for the Australian contribution to the International Cancer Genome Consortium (ICGC). Dr Cloonan is also well known for her work on miRNAs, being the first to apply a systems biology approach to the discovery of microRNA function, and the first to demonstrate that miRNA variants (isomiRs) had a biological role. In 2014, she described a new way in which miRNAs and mRNAs could interact, requiring a paradigm shift in the field, and she proposed a novel model to explain miRNA function. Nicole’s broad ranging biological interests are reflected in her publications, covering topics such as cancer, schizophrenia, malaria, stem cells, genome biology, and bioinformatics.